| Popis: |
Background: To date, the reactogenicity and immunogenicity of heterologous ChAdOx1-nCoV19/BNT162b2 (ChAd/BNT) vaccination remain unclear. Here, we systematically assessed the reactogenicity and immunogenicity of the heterologous ChAd/BNT vaccination regimens. Methods: The publicly available studies on heterologous COVID-19 vaccination were systematically searched on PubMed, Web of Science, Embase and MedRxiv for the available literature up to August 1, 2021. We evaluated the immunogenicity by the geometric mean titers (GMTs) of the neutralizing antibody and anti-spike IgG. The reactogenicity was evaluated using the pooled risk ratios (RRs) calculated by the random-effects model about the adverse events after vaccination. Subgroup analyses based on vaccination regimens and interval between the two doses of vaccines were conducted to evaluate the impact of the different regimens. Findings: Nine studies (n=4,286) were included in the analyses. Compared to the homologous ChAd/ChAd vaccination, the heterologous ChAd/BNT vaccination showed significantly higher immunogenicity (pooled GMTR [geometric mean titers ratio] in terms of the neutralizing antibody: 11·92 [95% CI 5·65-25·13, I2=49·1%, P |
