Diffuse Cortical Dysplasia in the Donor of Twin-to-Twin Transfusion Syndrome Following Fetoscopic Laser Photocoagulation: A Case Report
| Autor: | Kaori Miyana, Matsumoto Ayumi, Masaya Kubota, Itaru Hayakawa, Kazuhiro Muramatsu, Jin Muromoto |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Pregnancy 030219 obstetrics & reproductive medicine business.industry Brain damage 030105 genetics & heredity Cortical dysplasia medicine.disease Twin-to-twin transfusion syndrome 03 medical and health sciences 0302 clinical medicine Modeling and Simulation medicine Gestation Abnormality medicine.symptom Complication business Perfusion |
| Zdroj: | Journal of Fetal Medicine. :151-155 |
| ISSN: | 2348-8859 2348-1153 |
| DOI: | 10.1007/s40556-021-00304-8 |
| Popis: | Twin-to-twin transfusion syndrome (TTTS) is a severe gestational complication due to an imbalance of blood flow between monochorionic diamniotic twins. TTTS can cause brain damage, most commonly ischemic lesions, but there are only a few reports of cortical dysplasia. We report the case of a TTTS donor twin with diffuse cortical dysplasia. Fetoscopic laser photocoagulation was performed at 18 weeks of gestation, and no abnormalities were noted in the subsequent course of the pregnancy; however, infantile spasms developed at 4 months after birth, and brain magnetic resonance imaging revealed diffuse cortical dysplasia. It was bilateral and widespread. A genetic abnormality was suspected, but no pathogenic mutation was detected. Hypoperfusion may have altered the expression of guidance factors, resulting in abnormal cortical formation. |
| Databáze: | OpenAIRE |
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