ChemInform Abstract: Regioselective Synthesis of 9-((2-Hydroxyethoxy)methyl)-6- benzylaminopurine Analogue of Acyclovir

Autor:	Hassan B. Lazrek, M. L. Taha
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Base (chemistry) Stereochemistry Potassium Regioselectivity chemistry.chemical_element General Medicine Alkylation Medicinal chemistry Catalysis Solvent chemistry.chemical_compound chemistry Yield (chemistry) Tetrahydrofuran
Zdroj:	ChemInform. 27
ISSN:	0931-7597
DOI:	10.1002/chin.199608240
Popis:	The 6-benzylaminopurine 1 has been alkylated with (2-acetoxyethoxy)methylbromide 3, using trimethylsilylation and phase transfer catalysis procedures. The influence of the base, the solvent and the catalyst were studied. When the solid-liquid phase transfer catalysis was conducted in tetrahydrofuran in the presence of the potassium tert-butoxide and 18-crown-6, the reaction was regioselective to give 9-[(2-acetoxyethoxy)methyl]-6-benzylaminopurine 5 in 80% yield.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ee7b182ac2df911735473d7fba2ccd85 https://doi.org/10.1002/chin.199608240 Zobrazit plný text záznamu Plný text