Measuring serum beta2-microglobulin to predict long-term mortality in hemodialysis patients using low-flux dialyzer reuse

Autor:	Dung Nguyen Huu, Kien Nguyen Trung, Hai Nguyen Thi Thu, Cuong Phan The, Huong Nguyen Thi Thu, Quy Quyen Dao Bui, Tuan Nguyen Minh, Ha Do Manh, Kien Truong Quy, Dung Nguyen Thi Thuy, Toan Pham Quoc, Vinh Hoang Trung, Tomoko Usui, Thang Le Viet
Rok vydání:	2019
Předmět:	medicine.medical_specialty Chemical Health and Safety Surrogate endpoint Beta-2 microglobulin business.industry medicine.medical_treatment Amyloidosis General Medicine Dialyzer reuse 030204 cardiovascular system & hematology medicine.disease Group A Gastroenterology Group B 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Pharmacology (medical) Long term mortality 030212 general & internal medicine Hemodialysis General Pharmacology Toxicology and Pharmaceutics business Safety Research
Zdroj:	Therapeutics and Clinical Risk Management. 15:839-846
ISSN:	1178-203X
DOI:	10.2147/tcrm.s210822
Popis:	Purpose Beta2-microglobulin (β2-M) is recognized as a surrogate marker relating to the mechanisms of dialysis-associated amyloidosis. Few studies have evaluated the association of serum β2-M with clinical outcome in hemodialysis patients using high-flux type. However, study on patients using low-flux dialyzer reuse has not been done yet. Patients and methods Using serum β2-M level on predicting long-term mortality of hemodialysis patients was examined in 326 prevalent hemodialysis patients (45.59±14.46 years, hemodialysis duration of 47.5 (26-79) months, 186 males and 140 females). The patients were divided into 3 groups with equal number of patients, according to their serum β2-M levels: group A (n=109, serum β2-M concentration ≤55.7 mg/L), group B (n=109, serum β2-M level from 55.8 mg/L to 75.4 mg/L) and group C (n=108, serum β2-M concentration >75.4 mg/L). Results During the follow-up period of 5 years, there were 75 all-cause deaths (23.0%). Kaplan-Meier analysis revealed that all-cause mortality in the higher β2-M group was significantly higher compared to that in the lower β2-M groups (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ee19bbccd11ae3d26be60cb517290673 https://doi.org/10.2147/tcrm.s210822 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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