Fe-Catalyzed decarbonylative alkylation–peroxidation of alkenes with aliphatic aldehydes and hydroperoxide under mild conditions

Autor:	Qi-Qiang Wang, Rong Li, Luo Yang, Chuan-Shuo Wu
Rok vydání:	2019
Předmět:	010405 organic chemistry Chemistry Environmental Chemistry Alkyl radicals Alkylation 010402 general chemistry 01 natural sciences Pollution Medicinal chemistry 0104 chemical sciences Catalysis
Zdroj:	Green Chemistry. 21:269-274
ISSN:	1463-9270 1463-9262
DOI:	10.1039/c8gc02834f
Popis:	A convenient Fe-catalyzed decarbonylative alkylation–peroxidation of alkenes with aliphatic aldehydes and TBHP to provide chain elongated peroxides is developed, which is further applied to the one-pot synthesis of alkylated ketones. Aliphatic aldehydes were decarbonylated into 1°, 2° and 3° alkyl radicals at low temperature which subsequently allows the cascade construction of C(sp3)–C(sp3) and C(sp3)–O bonds via radical insertion and radical–radical coupling. Various alkenes including mono-substituted, terminally disubstituted or internally disubstituted styrenes bearing synthetically useful functional groups and electron-poor acrylates were tolerated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eda9e88c706c769257d3063e6de72f9a https://doi.org/10.1039/c8gc02834f Zobrazit plný text záznamu