L’ingénierie cutanée pour le traitement des brûlures graves
| Autor: | Thomas Leclerc, M. Trouillas, J.-J. Lataillade, E. Bey, B. Magne |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty integumentary system business.industry Regeneration (biology) Biochemistry (medical) Clinical Biochemistry Mesenchymal stem cell 030208 emergency & critical care medicine Hematology Surgery Cell therapy 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Tissue engineering medicine Severe burn Stem cell Contracture medicine.symptom Wound healing business |
| Zdroj: | Transfusion Clinique et Biologique. 24:245-250 |
| ISSN: | 1246-7820 |
| DOI: | 10.1016/j.tracli.2017.06.022 |
| Popis: | Severe burned patients need definitive and efficient wound coverage. Outcome of massive burns has been improved by using cultured epithelial autografts (CEA). Despite fragility, percentages of success take, cost of treatment and long-term tendency to contracture, this surgical technique has been developed in few burn centres. First improvements were to combine CEA and dermis-like substitute. Cultured skin substitutes provide earlier skin closure and satisfying functional result. These methods have been used successfully in massive burns. Second improvement was to allow skin regeneration by using epidermal stem cells. Stem cells have capacity to differentiate into keratinocytes, to promote wound repair and to regenerate skin appendages. Human mesenchymal stem cells contribute to wound healing and were evaluated in cutaneous radiation syndrome. Skin regeneration and tissue engineering methods remain a complex challenge and offer the possibility of new treatment for injured and burned patients. |
| Databáze: | OpenAIRE |
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