MHC I Expression Predicts Response to Checkpoint Inhibitors in Metastatic Urothelial Carcinoma but Lacks Prognostic Value in Localized Disease
| Autor: | Julia Slotta-Huspenina, Kristina Schwamborn, Katja Steiger, Ricarda Simon, Florian Paul Kirchhoff, Jakob Wolf Büchler, Julia Fiedler, Margitta Retz, Roman Nawroth, Christoph Ritschel, Jürgen Erich Gschwend, Thomas Horn |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Bladder Cancer. 8:269-276 |
| ISSN: | 2352-3735 2352-3727 |
| DOI: | 10.3233/blc-211604 |
| Popis: | BACKGROUND: Loss of MHC I expression is a tumoral escape mechanism, part of the process of immunoediting. MHC expression patterns and their prognostic and predictive value have not been studied in urothelial carcinoma of the bladder (UC) so far. OBJECTIVE: To correlate the expression of MHC I and MHC II with prognosis after curative treatment, response to chemotherapy and checkpoint inhibition. PATIENTS AND METHODS: We analyzed different patient cohorts for their expression of MHC I(HLA-A/B/C) and II (HLA-DR/DP/DQ) and examined potential correlations with prognosis and response to cisplatin-based chemotherapy or PD-1/PD-L1 directed immunotherapy. RESULTS AND LIMITATIONS: Overall, MHC expression was analyzed in 246 patients, and complete MHC I loss was seen in 29.7% of patients. In 35% of patients aberrant tumoral expression of MHC II was observed. In a homogeneous cohort of 149 patients with cystectomy with curative intent there were no significant differences in survival between the MHC expression groups. MHC I+ and MHC II+ patients had higher infiltration densities with CD8+ T effector cells. An analysis of 77 additional patients (cohort II) with neoadjuvant chemotherapy revealed no associations of MHC status with response defined as |
| Databáze: | OpenAIRE |
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