Engineered IL‐10: A matter of affinity
| Autor: | Ruben Fernandez-Santamaria, Pattraporn Satitsuksanoa |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Allergy. 77:1067-1069 |
| ISSN: | 1398-9995 0105-4538 |
| DOI: | 10.1111/all.15132 |
| Popis: | Pleiotropic roles of IL-10. Immune cells including regulatory T cells and B cells, ILCregs, macrophages, and DCs produce IL-10, which exerts both anti-inflammatory and pro-inflammatory effects. In an anti-inflammatory state, IL-10 suppresses inflammatory signals from several immune cells. In a pro-inflammatory state, IL-10 can induce CD8+ T cells to release IFN-γ and granzyme B. The underlying mechanism that defines anti-inflammatory and pro-inflammatory activities of IL-10 depends on the binding affinity of IL-10 to its receptors (IL-10Rα and IL-10Rβ). The dimerization of the IL-10 complex activates STAT1/STAT3 and diversifies the biological effects of IL-10. In hindsight, high-affinity to IL-10Rβ leads to both anti-inflammatory and pro-inflammatory activities while low-affinity to IL-10Rβ only induces anti-inflammatory functions. |
| Databáze: | OpenAIRE |
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