The Impact of P53 and KI67 Expression in Endometrial Cancer and its Effect on Survival

Autor:	Muzaffer Sarici, Tuğba Karadeniz, Zekiye Sahin, Burak Bayraktar
Rok vydání:	2021
Předmět:	medicine.medical_specialty medicine.drug_class business.industry Endometrial cancer Retrospective cohort study Gynecologic oncology medicine.disease Gastroenterology Dissection Estrogen Internal medicine Progesterone receptor medicine Carcinoma Immunohistochemistry business
Zdroj:	Gynecology Obstetrics & Reproductive Medicine. :1-7
ISSN:	2602-4918 1300-4751
Popis:	OBJECTIVE: This study was conducted to evaluate the relationship of p53 and Ki67 expression with prognostic factors in patients who underwent surgery due to a diagnosis of endometrial cancer, and to evaluate their use as molecular markers that can help with survival prediction. STUDY DESIGN: This retrospective cohort study included patients who underwent surgery for endometrial cancer indication at the Gynecologic Oncology Clinic of the University of Health Sciences Tepecik Training and Research Hospital between 2011 and 2019, and whose p53 and Ki67 from the dissected material were pathologically studied and who underwent pelvic/paraaortic lymph dissection between the relevant dates. RESULTS: The study included 140 patients who met the inclusion criteria, 60% (n=84) of whom had endometrioid type endometrial carcinoma and 40% (n=56) had non-endometrioid type endometrial carcinoma. Estrogen and progesterone receptor positivity was significantly higher in the endometrioid type endometrial carcinoma group (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eb0153f49e26e25a7b0e1bd4029ec83c https://doi.org/10.21613/gorm.2021.1194 Zobrazit plný text záznamu