Ultrasound-Enhanced Distribution and Treatment Efficacy of Dox-Loaded Intratumoral In Situ Forming Implants in Murine HCT-15 Tumors
| Autor: | Agata A. Exner, Selva Jeganathan, Emily Budziszewski, Michael C. Kolios, Christopher Hernandez, Peter Bielecki |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Hyperthermia Chemotherapy Therapeutic ultrasound business.industry medicine.medical_treatment Pharmacology medicine.disease 03 medical and health sciences PLGA chemistry.chemical_compound 030104 developmental biology chemistry Drug delivery medicine Distribution (pharmacology) Doxorubicin Implant business medicine.drug |
| Zdroj: | 2018 IEEE International Ultrasonics Symposium (IUS). |
| DOI: | 10.1109/ultsym.2018.8580108 |
| Popis: | Local drug delivery systems, such as in situ forming implants (ISFIs), allow for sustained elevated drug concentration directly at the tumor site. However, these systems have been challenging to translate into clinical practice due to poor drug penetration through the implant/tumor boundary. Ultrasound (US) has emerged as a popular approach to enhance drug release and cellular drug uptake from nanoparticles, but little work has been done with its use in combination with ISFIs. In this study, ISFIs were intratumorally injected and treated with therapeutic ultrasound (TUS). A significant (p |
| Databáze: | OpenAIRE |
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