Cu(i)-catalyzed double C–H amination: synthesis of 2-iodo-imidazo[1,2-a]pyridines

Autor:	P. L. Sangwan, K. Ranjith Reddy, Ravi Shankar, Parthasarthi Das, Divya Dheer, Santosh K. Rath
Rok vydání:	2016
Předmět:	Active ingredient Reaction conditions 010405 organic chemistry Chemistry General Chemical Engineering chemistry.chemical_element Regioselectivity General Chemistry 010402 general chemistry Iodine 01 natural sciences 0104 chemical sciences Catalysis Organic chemistry Amination
Zdroj:	RSC Advances. 6:38033-38036
ISSN:	2046-2069
DOI:	10.1039/c6ra02953a
Popis:	An iodine/CuI mediated double oxidative C–H amination reaction has been developed for the synthesis of 2-iodo-imidazo[1,2-a]pyridines. The salient features of this methodology are mild reaction conditions and high regioselectivity. The designed compounds e.g. 2-iodo-imidazo[1,2-a]pyridines (3e) may serve as active pharmaceutical ingredients (APIs) of marketed drugs like saripidem and nicopidem. Further saripidem was synthesised by using 3e as an intermediate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eabe44dd6ba73d6d9be707fda02c15bb https://doi.org/10.1039/c6ra02953a Zobrazit plný text záznamu