Hyperdry Human Amniotic Membrane (HD-AM) is Supporting Aciclovir Included Device of Poly-N-p-Vinyl-Benzyl-D-Lactonamide (PVLA) Sphere for Treatment of HSV-1 Infected Rabbit Keratitis Model
| Autor: | Masato Taguchi, Kiyoshi Katou, Toshio Nikaido, Takuma Suzuki, Mitsuaki Goto, Kazuaki Nakagawa, Masahiro Omori, Motonori Okabe, Fumitaka Hiramoto, Kaixuan Zhou, Moustafa Fathy Omar, Ayaka Toda, Toyohiko Ushijima, Yoshihiro Nomura, Hiroki Waki, Makoto Nakamura, Michiko Suzuki, Shigeru Saito, Etsuko Furuichi, Kenichi Arai, Toshio Kasama, Toshiko Yoshida |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
viruses
HSL and HSV Pharmacology medicine.disease_cause 01 natural sciences Keratitis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine Aciclovir 010405 organic chemistry business.industry virus diseases 030208 emergency & critical care medicine Eye infection medicine.disease Virology 0104 chemical sciences Membrane chemistry Drug delivery Glutaraldehyde Irritation business medicine.drug |
| Zdroj: | Journal of Biotechnology & Biomaterials. |
| ISSN: | 2155-952X |
| DOI: | 10.4172/2155-952x.1000251 |
| Popis: | The human amniotic membrane (AM) has been widely used in ophthalmic surgery, including in ocular surface reconstruction. However, whether AM is effective for the release of impregnated drugs is unknown. Hyperdry-AM (HD-AM), glutaraldehyde cross-linked HD-AM (Glu HD-AM) and a solvent of poly-N-p-vinylbenzyl- D-lactonamide (PVLA) did not cause irritation to the rabbit eye. Although the concentration of residual glutaraldehyde in Glu HD-AM was approximately 40 ppm (dry-weight basis), no eye irritation was observed. Acyclovir (ACV) containing PVLA-bearing spheres (ACV/PVLA) was loaded into HD-AM (ACV/PVLA HD-AM), and then the therapeutic efficacy of ACV/PVLA HD-AM was compared with that of ACV/PVLA solution in a herpes simplex virus-1 (HSV-1) eye infection model. The former was more effective against ocular infection, and its efficacy was dose- and volume-dependent. Thus, ACV/PVLA HD-AM sheets were very effective as a curative treatment for eye infection with HSV-1. HD-AM can be function as drug delivery system. In the future, it may be possible to combine HD-AM and PVLA in a device that can control the release of hydrophobic medicines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|