β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
| Autor: | Qian Chen, Oleg Chertov, S. N. Bykovskaia, O. M. Z. Howard, D. Yang, J. I. Shogan, M. Anderson, J. M. Schröder, M. J. Buffo, Ji Ming Wang, Joost J. Oppenheim |
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| Rok vydání: | 1999 |
| Předmět: |
Multidisciplinary
integumentary system T cell fungi Antigen presentation chemical and pharmacologic phenomena hemic and immune systems Dendritic cell respiratory system Biology CCL5 Cell biology medicine.anatomical_structure Immunology medicine CCL25 Antigen-presenting cell CC chemokine receptors CXCL16 |
| Zdroj: | Science. 286:525-528 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.286.5439.525 |
| Popis: | Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human β-defensins are also chemotactic for immature dendritic cells and memory T cells. Human β-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells. The β-defensin–induced chemotaxis was sensitive to pertussis toxin and inhibited by antibodies to CCR6. The binding of iodinated LARC, the chemokine ligand for CCR6, to CCR6-transfected cells was competitively displaced by β-defensin. Thus, β-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6. |
| Databáze: | OpenAIRE |
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