ChemInform Abstract: SYNTHESIS AND CONFORMATION OF (5R,8R,10R)-8-(METHYLTHIOMETHYL)ERGOLINE-6-CARBOXAMIDINE

Autor:	Hans-Rudolf Loosli, René Nordmann
Rok vydání:	1985
Předmět:	chemistry.chemical_compound chemistry Thiourea Stereochemistry Cyclohexane conformation medicine Cyanamide General Medicine Guanidine Ergoline medicine.drug
Zdroj:	Chemischer Informationsdienst. 16
ISSN:	0009-2975
DOI:	10.1002/chin.198539345
Popis:	The title compound 7 and two related novel ergolines have been synthesised from (5R,8R,10R)-8-(methyl-thiomethyl)ergoline-6-carbonitrile (4). The guanidine function of 7 induces a boat conformation of ergoline-ring D, as demonstrated by a careful NMR spectroscopic analysis of 7 and its N-hydroxy congener 6. Diphenylphosphinodithioic acid has been used to convert the cyanamide function of 4 into the thiourea function at (5R,8R,10R)-8-(methylthiomethyl)ergoline-6-thiocarboxamide (5).
Databáze:	OpenAIRE
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