SURVEILLANCE OF ANTIBIOTIC RESISTANCE IN CLINICAL ISOLATES OFSTREPTOCOCCUS PNEUMONIAECOLLECTED IN BELGIUM DURING WINTER 2000-2001

Autor: I. Surmont, L. Van Nimmen, B. Gordts, Raymond Vanhoof, Youri Glupczynski, D. Govaerts, R. Cartuyvels, H. Van Landuyt, M. Carpentier, O. Fagnart, M. Van De Vyvere, E. Van Bossuyt, I. Mans, S. Damée, K. Magerman, R. Van Noyen, M.-G. Garrino
Rok vydání: 2003
Předmět:
Zdroj: Acta Clinica Belgica. 58:117-125
ISSN: 2295-3337
1784-3286
Popis: A total of 314 isolates of Streptococcus pneumoniae collected by 10 different laboratories were tested for their susceptibility by using a microdilution technique following NCCLS recommendations. The following antibiotics were included: penicillin, ampicillin, amoxicillin, amoxicillin/clavulanate, cefaclor, cefuroxime, cefotaxime, imipenem, ciprofloxacin, gemifloxacin, levofloxacin, erythromycin, clarithromycin, azithromycin, miocamycin, clindamycin and tetracycline. The insusceptibility rate (IR) to penicillin was 21.0% [10.8% intermediate (greater than or equal to0.12-1 mug/mL) and 10.2 % high-level (greater than or equal to2 mug/mL)], to cefotaxime 7.3 % [3.5 % intermediate (greater than or equal to 1 mug/mL) and 3.8 % high-level (greater than or equal to2 mug/mL)], to imipenem 3.8 % [3.8 % intermediate (greater than or equal to0.25-0.5 mug/mL) and 0 % high-level (greater than or equal to1 mug/mL)], to ciprofloxacin 11.2 % [8.3 % intermediate (2 mug/mL) and 3.9 % high-level (greater than or equal to4 mug/mL)], to erythromycin 30.3 % [3.5 % intermediate (0.5 mug/mL) and 26.8 % high-level (greater than or equal to1 mug/mL)] and to tetracycline 38.5 % [0.9 % intermediate (4 mug/mL) and 37.6 % high-level (greater than or equal to8 mug/mL)]. No decreased susceptibility was found for gemifloxacin (greater than or equal to0.5 mug/mL). This compound was the most active with MIC50, MIC90 and an IR of 0.015 mug/mL, 0.03 mug/mL, and 0 % respectively, followed by amoxicillin/ clavulanate, amoxicillin and imipenem (MIC50, MIC90 and IR: 0.015 mug/mL, 1 mug/mL, 1.6 %/ 0.015 mug/mL, 1 mug/mL, 1.9 %/ 0.008 mug/mL, 0.12 mug/mL, 3.8 % respectively). Compared to the 1999 surveillance, penicillin and tetracycline-insusceptibility increased with 4.9 % and 15.6% respectively, while cefotaxime, erythromycin and ciprofloxacin insusceptibility decreased with 5.4 %, 5.8 % and 4.4 % respectively. MICs of all beta-lactams rose with those of penicillin for penicillin-insusceptible isolates. Imipenem, cefotaxime, amoxicillin and amoxicillin/clavulanate were generally 4, 2, 1 and 1 doubling dilutions respectively more potent than penicillin on these isolates while ampicillin, cefuroxime and cefaclor were generally 1, 2 and 4 dilutions respectively less potent. Most penicillin-insusceptible isolates remained fully susceptible to amoxicillin/clavulanate (92.4 %), amoxicillin (90.9 %) and imipenem (81.8 %). Erythromycin-tetracycline insusceptibility was the most common resistance phenotype (14.3 %). Three- and four-fold resistance was found in 12.4 % and 1.6 % respectively of the isolates. Most penicillin-insusceptible isolates were of capsular types 14 (22.7 %), 23 (21.2 %), 6 (18.2 %), 9 (13.6 %) and 19 (12.1 %).
Databáze: OpenAIRE
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