High Dose Inhalation with Gaseous Nitric Oxide in COVID-19 Treatment

Autor: E. V. Pechyonkin, A. V. Kovrizhkin, A. V. Pekshev, A. B. Vagapov, N. A. Sharapov, A. F. Vanin
Rok vydání: 2022
Předmět:
Zdroj: Biophysics. 67:1023-1032
ISSN: 1555-6654
0006-3509
DOI: 10.1134/s0006350922060185
Popis: Abstract A method of treatment of a new coronavirus infection COVID-19 in patients undergoing high flow oxygenation is proposed and technically implemented; the method is based on high-dose inhalation of gaseous nitric oxide (NO) with the patient’s spontaneous breathing. The results of the treatment of this disease demonstrating the high efficiency of the new method are presented. A possible mechanism of the blocking effect of high doses of inhaled nitric oxide on the replication of the SARS-CoV-2 virus is discussed; it is based on the formation of dinitrosyl iron complexes in the respiratory tract and lungs of COVID-19 patients with thiol-containing ligands acting as donors of NO and nitrosonium NO+ cations in a living organism that have a cytotoxic effect on the SARS CoV-2 virus.
Databáze: OpenAIRE
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