PS-151 Altered Microrna Expression In Umbilical Cord Blood Of Infants With Hypoxic Ischaemic Encephalopathy

Autor:	Geraldine B. Boylan, Brian H. Walsh, Gerard Clarke, Sue Grenham, AM Looney, Ted Dinan, Gerry Moloney, Deirdre M. Murray, John F. Cryan
Rok vydání:	2014
Předmět:	Pediatrics medicine.medical_specialty Microarray business.industry Disease medicine.disease Bioinformatics Neuroprotection Umbilical cord Hypoxic ischaemic encephalopathy Perinatal asphyxia medicine.anatomical_structure Pediatrics Perinatology and Child Health microRNA medicine business Stroke
Zdroj:	Archives of Disease in Childhood. 99:A165.3-A166
ISSN:	1468-2044 0003-9888
DOI:	10.1136/archdischild-2014-307384.447
Popis:	Background To guide the neuroprotective management of infants with hypoxic ischaemic encephalopathy (HIE), early identification is essential. MicroRNAs are small non-coding RNA molecules with potential for use as biological markers for disease. The aim of this study was to investigate the expression profile of miRNA in umbilical cordblood (UCB) from infants with HIE. Methods Full term infants with perinatal asphyxia (PA) were identified by a cord pH ± 1.3) were validated using quantitative RT-PCR (qRT-PCR). Results On microarray 70 miRNAs were differentially expressed between the HIE and the control group. Of these hsa-miR-374a was the most significantly downregulated in HIE vs controls (p Conclusion To our knowledge, this is the first study to describe the miRNA profile present in umbilical cord blood following HIE. Our results confirm the potential utility of miRNA biomarkers in the early diagnosis of HIE.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e9b60c5677feb1fc0e06dff00cf9e8f4 https://doi.org/10.1136/archdischild-2014-307384.447 Zobrazit plný text záznamu