(S)-(−)-1-Amino-2-Methoxymethylpyrrolidine (SAMP) and (R)-(+)-1-Amino-2-Methoxymethylpyrrolidine (RAMP), Versatile Chiral Auxiliaries

Autor:	Peter Dr Fey, Dieter Enders, Helmut Kipphardt
Rok vydání:	2003
Předmět:	chemistry.chemical_classification Acylation chemistry.chemical_compound Hydrolysis Potassium hypochlorite chemistry Halide Organic chemistry Alkylation Medicinal chemistry Alkyl Tetrahydrofuran Sodium hydride
Zdroj:	Organic Syntheses
DOI:	10.1002/0471264180.os065.23
Popis:	(S)-(−)-1-amino-2-methoxymethylpyrrolidine (SAMP) and (R)-(+)-1-amino-2-methoxymethylpyrrolidine (RAMP), versatile chiral auxiliaries product: (R)-(+)-1-amino-2-methoxymethylpyrrolidine (RAMP) intermediate: hydroxymethylpyrrolidine intermediate: (S)-(−)-1-formyl-2-hydroxymethylpyrrolidine. intermediate: (S)-(+)-2-methoxymethylpyrrolidine. intermediate: (S)-(−)-1-amino-2-methoxymethylpyrrolidine (SAMP) Keywords: acylation; alkylation, O-alkylation; hydrolysis, amides; rearrangements; reduction, CO2H CH2OH; potassium hypochlorite solution, preparation; tetrahydrofuran; alkyl halides, toxicity; sodium hydride, handling
Databáze:	OpenAIRE
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