Pathological Aspects of Radiofrequency Catheter Ablation of the Canine Atrioventricular Node and Bundle of His
| Autor: | Takeshi Kasajima, Kenzo Hirao, Toshio Nishikawa, Michio Tanaka, Shutaro Satake, Akihiro Masuda, Masaya Sugiura, Yutaka Kawahara, Tokuhiro Kawara, Kazushi Tanaka |
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| Rok vydání: | 1991 |
| Předmět: |
Dense connective tissue
medicine.medical_specialty business.industry Heart block medicine.medical_treatment Catheter ablation General Medicine Anatomy medicine.disease Bundle of His Atrioventricular node Pathology and Forensic Medicine medicine.anatomical_structure medicine Histopathology business Pathological Atrioventricular block |
| Zdroj: | Pathology International. 41:487-498 |
| ISSN: | 1440-1827 1320-5463 |
| Popis: | Radiofrequency catheter ablation of the atrioventricular (AV) node or bundle of His was performed in 12 adult mongrel dogs. The aim was to create chronic incomplete AV block (first- and second-degree AV block) and to examine the histopathology of the ablated lesions. However, the late electrophysiological results (2-4 weeks follow-up) were various: normal in 2 dogs, mild PR prolongation (less than 50%) in 2 dogs, first-degree AV block (PR prolongation greater than or equal to 50%) in 2 dogs, second-degree AV block in 2 dogs, complete AV block in 4 dogs. The maximally ablated area (%) of the atrioventricular conduction system in serial histologic sections from dogs with these conditions was 69%, 75%, 89.5%, 95% and 99.5%, respectively. The number of intact conduction cells at the maximally ablated site varied from 6 to 30 in the four cases of incomplete AV block. The mean ablated volume (%) of either the AV node or penetrating His bundle correlated roughly with the degree of AV block. The ablated lesions were well demarcated and almost replaced by dense fibrous tissue at 4 weeks. Interruption (3 dogs) or thinning (1 dog) of the endocardial elastic lamellae was detected, in association with endocardial thickening (mean 913 microns). Endocardial thrombi were found in 3 dogs (2 fresh, 1 organized). We conclude that radiofrequency catheter ablation does not cause severe complicated lesions. Several possible conditions for creating chronic incomplete AV block are discussed. |
| Databáze: | OpenAIRE |
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