Coronary Thrombolysis with Recombinant Tissue Plasminogen Activator
| Autor: | John Ducas, Kevin Wolfe, Richard M. Prewitt, J. Norman Patton, Shian Gu |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cardiac output business.industry medicine.medical_treatment Thrombolysis Anterior Descending Coronary Artery Critical Care and Intensive Care Medicine medicine.disease Thrombosis Coronary circulation Route of administration medicine.anatomical_structure Coronary thrombosis Anesthesia medicine Thrombus Cardiology and Cardiovascular Medicine business |
| Zdroj: | Chest. 100:201-206 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.100.1.201 |
| Popis: | We employed a canine model of coronary thrombosis, induced by injection of radioactive blood clot, via a catheter placed in the left anterior descending coronary artery, to compare effects of recombinant tissue plasminogen activator (rtPA) administered intravenously and administered directly into the coronary circulation. A control group did not receive rtPA. Compared with controls, both rtPA regimens induced coronary thrombolysis. However, compared with intravenous administration, rate and extent of coronary thrombolysis were increased with intracoronary administration. Most likely, the enhanced thrombolysis with intracoronary administration is explained by an increase in delivery of the drug to the thrombus. |
| Databáze: | OpenAIRE |
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