Microwave-Assisted Synthesis and Molecular Docking Studies of Fluorinated 1,3,4-Oxadiazole Derivatives as Antimicrobial Agent
| Autor: | Mohd Arif Pathan, Amol U. Khandebharad, Santosh Raut, B. K. Dhotre, M. A. Patharia |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
biology 010405 organic chemistry Organic Chemistry Hydrazide biology.organism_classification Antimicrobial 01 natural sciences Biochemistry Combinatorial chemistry Corpus albicans 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry Proton NMR Bioorganic chemistry Antibacterial activity Bacteria Benzoic acid |
| Zdroj: | Russian Journal of Bioorganic Chemistry. 46:1110-1116 |
| ISSN: | 1608-330X 1068-1620 |
| DOI: | 10.1134/s1068162020060059 |
| Popis: | A series of phenyl-5-(2,3,5,6-tetrafluoro-phenyl)-[1,3,4]-oxadiazole were prepared from 2,3,5,6-tetrafluoro-benzoic acid hydrazide by treatment with various substituted benzoic acid in the presence of phosphorus oxychloride using conventional as well as microwave-assisted methods. Evaluation of antibacterial activity of synthesized compound against S. aures, S. pyogenes, S. typhi and Pseudomonas species and antifungal activity against C. albicans and A. niger has been carried out. The compounds (Vb) and (Ve) showed significant activity against both bacteria and fungi. Some of the compounds has shown moderate activity against both the bacteria and fungi. The molecular docking studies also done which support the antimicrobial activity exhibited high inhibition constant and binding energy. The chemical structures of all the synthesized compounds were elucidated by their IR, 1H NMR and mass spectra. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink