Synthesis of ?-keto acids via azlactones of 2-(acylamino)-3-alkyl(or aryl)acrylic acids, and a new synthesis of 3-methyl-2-oxovaleric acid

Autor:	Z. S. Kagan
Rok vydání:	1958
Předmět:	chemistry.chemical_classification Hydrolysis chemistry.chemical_compound General method Chemistry Aryl Butanone Condensation Acetone Hippuric acid Organic chemistry General Chemistry Alkyl
Zdroj:	Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 6:1508-1510
ISSN:	1573-9171 0568-5230
DOI:	10.1007/bf01169758
Popis:	1. The condensation of aldehydes or ketones with N-acylglycines with subsequent hydrolysis of the resulting azlactones of 2-(acylamino)-3-alkyl(or aryl) acrylic acids must be regarded as another general method for the synthesis of α-keto acids. 2. The synthesis of 3-methyl-2-oxobutyric acid by condensation of acetone with hippuric acid and subsequent hydrolysis of the azlactone was repeated. 3. A new synthesis of 3-methyl-2-oxovaleric acid is described, namely, condensation of butanone with hippuric acid and subsequent hydrolysis of the resulting azlactone of 2-benzamido-3-methyl-2-pentenoic acid.
Databáze:	OpenAIRE
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