| Popis: |
The ability of smooth muscles to compensate for increased functional demand is associated with alterations in the expression and function of a number of contractile proteins and other proteins that are involved in excitation-contraction coupling and active force generation. However, continuation of the structural alterations in the muscle cells of the bladder wall leads ultimately to decreased compliance and impaired emptying. Decompensation of the bladder muscle with persistent outlet obstruction is likely to be caused by breakdown of the structure and function of proteins that form the contractile apparatus and those that enable smooth muscle cells to take up, store, and release Ca 2+ . This would affect the activation of the contractile apparatus. In this chapter, we review the contractile proteins that are important for force production and maintenance in smooth muscles and the effect of outlet obstruction on the expression of these proteins. |
