Child-related and parental predictors for thelarche in a general population of girls: the PANIC study

Autor: Saija E. Savinainen, Jarmo Jääskeläinen, Anna Viitasalo, Taisa Sallinen, Timo A. Lakka
Rok vydání: 2020
Předmět:
Zdroj: Pediatric Research. 88:676-680
ISSN: 1530-0447
0031-3998
DOI: 10.1038/s41390-020-0802-0
Popis: BACKGROUND Obesity has been associated with earlier thelarche, whereas other predictors for it remain unclear. METHODS We studied child-related and parental predictors for earlier thelarche in 195 girls aged 6-8 years followed up for 2 years. A physician evaluated breast development by inspection and palpation. Body fat percentage (BF%) was measured by dual-energy X-ray absorptiometry, diet by food records, and physical activity and sedentary time by body movement and heart rate monitors. Parental education, smoking, and alcohol consumption and household income were assessed by questionnaires. Gestational age, birth weight, and maternal prepregnancy BMI were obtained from hospital registers. Predictors for thelarche were examined using logistic regression analysis adjusted for age and follow-up time. RESULTS The incidence of thelarche during 2 years increased by 11% (OR 1.11, CI 1.06-1.17, p
Databáze: OpenAIRE