Investigating Human Dendritic Cell Immune Responses to Borrelia burgdorferi
| Autor: | Lauren M. K. Mason, Joppe W. R. Hovius |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
biology Phagocytosis chemical and pharmacologic phenomena Human skin Dendritic cell bacterial infections and mycoses biology.organism_classification In vitro 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system Borrelia Immunology Borrelia burgdorferi Ex vivo 030215 immunology |
| Zdroj: | Methods in Molecular Biology ISBN: 9781493973828 |
| DOI: | 10.1007/978-1-4939-7383-5_21 |
| Popis: | Dendritic cells (DCs) are professional antigen-presenting cells that recognize and phagocytose pathogens, and help to orchestrate adaptive immune responses to combat them. DCs are abundant in the skin where Borrelia burgdorferi first enters the body during a tick bite, and are thus critical in determining the initial stages of the innate and adaptive immune responses against Borrelia. Here, we describe two methods to study the response of DCs to Borrelia; an in vitro approach using monocyte-derived DCs (moDCs) and an ex vivo approach using a human skin model. |
| Databáze: | OpenAIRE |
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