Application of PMR Spectrometry in Quantitative Analysis of Praziquantel in Pharmaceutical Preparations
| Autor: | F. I. Khattab, N. A. El Ragehy, A. K. S. Ahmad, S. Z. El-khateeb |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Chromatography
Maleic acid Mass spectrometry Atomic and Molecular Physics and Optics Proton magnetic resonance Analyse qualitative Dosage form Analytical Chemistry Praziquantel chemistry.chemical_compound Qualitative analysis chemistry medicine Quantitative analysis (chemistry) Spectroscopy medicine.drug |
| Zdroj: | Spectroscopy Letters. 23:505-514 |
| ISSN: | 1532-2289 0038-7010 |
| DOI: | 10.1080/00387019008054432 |
| Popis: | A simple, accurate and specific proton magnetic resonance (PMR) procedure is developed for the assay of praziquantel and its tablets. The method involves comparing the integral of the multiplet of praziquantel (positioned at δ 7.3 ppm) to that of the sharp singlet signal (positioned at δ 6.3 ppm) of maleic acid which is used as intenal standard. The method reported in this study gives accurate and reproducible results when applied for the analysis of both authentic drug and its tablets. In addition the PMR spectrum helps in confirming the identity and purity of the drug. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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