Serum β-glucuronidase activity as a biomarker for acute cholinesterase inhibitor pesticide poisoning
| Autor: | Amal Hafez, Kadry M. Sadek, Doha M. Beltagy |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty biology business.industry Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Pesticide Toxicology Control subjects Gastroenterology Acute toxicity 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Internal medicine biology.protein Medicine Biomarker (medicine) In patient business Glucuronidase activity 030217 neurology & neurosurgery Butyrylcholinesterase Cholinesterase |
| Zdroj: | Toxicology and Industrial Health. 34:891-897 |
| ISSN: | 1477-0393 0748-2337 |
| Popis: | β-glucuronidase (BG) activity is a promising biomarker for diagnosis and prognosis after exposure to organophosphorous (OP) pesticides. The aim of this study was to evaluate the changes in serum BG activity in patients with acute OP poisoning and to determine whether these changes correlate with the severity of poisoning. Thirty patients with anticholinesterase pesticide poisoning were included, besides 10 healthy volunteers as a control group. Serum activities of butyrylcholinesterase (BuChE) and BG were measured for each subject on admission, then after 12 and 24 h. Serum levels of BuChE and BG in poisoned patients were significantly different from the control subjects; these differences persisted in repeated measurements. Moreover, the serum levels showed significant differences within each group of the three time points. A significant negative correlation was found between the serum activities of BuChE and BG in all groups at the three time points. In conclusion, serum BG activity seems a reliable marker for OP poisoning even when measured at 24 h after poisoning. |
| Databáze: | OpenAIRE |
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