Thermal, non-catalyzed Huisgen cycloaddition for the preparation of 4,5-bis(trimethylsilyl)-1H-1,2,3-triazoles

Autor:	Steven R. Larson, Kent C. Hackbarth, Ronald G. Brisbois, Percy Y. Griffin, Aubrey J. Ellison, Alexandra M. Bergan
Rok vydání:	2013
Předmět:	chemistry.chemical_classification 1 2 3-Triazole Trimethylsilyl Organic Chemistry Alkyne Biochemistry Cycloaddition chemistry.chemical_compound chemistry Acetylene Bis(trimethylsilyl)acetylene Drug Discovery Organic chemistry Azide Pharmacophore
Zdroj:	Tetrahedron Letters. 54:272-276
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2012.11.019
Popis:	The 1,2,3-triazole scaffold is an important pharmacophore and a versatile, increasingly leveraged, substructure in biochemical, materials, polymer, and metal-coordinating applications. Continuing advances in 1,2,3-triazole construction, by either non-catalyzed or metal-catalyzed azide/alkyne cycloaddition, foster further creative use. The work reported here establishes a general protocol for the synthesis of 4,5-bis(trimethylsilyl)-1H-1,2,3-triazoles via thermal Huisgen cycloaddition between azides and bis(trimethylsilyl)acetylene.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e7ae2c8a154ff3eb37b7ad4abd2aa0ef https://doi.org/10.1016/j.tetlet.2012.11.019 Zobrazit plný text záznamu Full Text from ScienceDirect