Changes in mandibular bone mineral density during pregnancy and lactation in mice
| Autor: | Yasuhiro Kato, Hajime Kuno, Shiro Yamada, Tetsuhito Kawase, Atsushi Mori, Atsushi Shinohara, Yoshiaki Kazaoka, Tetsuo Masahashi |
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| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | Japanese Journal of Oral & Maxillofacial Surgery. 45:789-794 |
| ISSN: | 2186-1579 0021-5163 |
| Popis: | We studied the changes in mandibular bone mineral density (M-BMD) associated with pregnancy and lactation in mice.MethodsFive female ddy mice were used in each of the following groups: control groups consisting of non-pregnant mice 8, 11, 14, 17 weeks old; pregnant, non-lactating groups consisting of 8-week-old pre-pregnant mice, 11-week old post partum mice, and 14-and 17-week-old puerperal, non-lactating mice; and pregnant, lactating groups, used to investigate the effect of lactation on M-BMD, consisting of 11-week-old post partum mice, and 14-and 17-week-old puerperal, lactating mice (both groups lactating for 3 weeks). Portions of the left mandible were resected, and bone mineral content (BMC) was measured by dual-energy x-ray absorptiometry (DXA; ultrahigh resolution mode, Hologic QDR 1000). Mandibular area (cm 2) was measured with the use of an image analysis program (Ultimage, I & I). Bone mineral density was obtained from BMC and mandibular area. A factorial ANOVA was used for statistical analysis.Results1) There was no difference in M-BMD associated with pregnancy.2) M-BMD was significantly lower in puerperal 14-week-old lactating mice, but this difference rapidly disappeared after lactation was discontinued. |
| Databáze: | OpenAIRE |
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