Volumetric capnography: a promising lung function test in cystic fibrosis?
| Autor: | Olga Lagiou, Florian Wyler, Ilias Theodorakopoulos, Sotirios Fouzas, Anne-Christianne Kentgens, Philipp Latzin, Sophie Yammine, Bettina Sarah Frauchiger |
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| Rok vydání: | 2020 |
| Předmět: |
Reproducibility
business.industry Dead space Lung Clearance Index medicine.disease Cystic fibrosis Pulmonary function testing law.invention 03 medical and health sciences 0302 clinical medicine 030228 respiratory system law Ventilation (architecture) Extensive data Volumetric capnography Medicine 030212 general & internal medicine business Nuclear medicine |
| Zdroj: | Paediatric respiratory physiology and sleep. |
| DOI: | 10.1183/13993003.congress-2020.3954 |
| Popis: | Introduction: Volumetric Capnography (VCap) is a quick and easy method to assess ventilation inhomogeneity (VI). It requires only few tidal breaths and no extensive data processing. Thus, VCap omits challenges that currently limit the use of established VI-tests, such as Multiple Breath Washout (MBW). Aim: We assessed VCap feasibility, reproducibility and comparability with the Lung Clearance Index (LCI) of Cystic Fibrosis (CF) N2-MBW data. Methods: We included 317 N2-MBW trials from 61 healthy and 54 CF children (age 9.5±4.1 and 10.1±3.9 years) with at least two good quality MBW trials. Primary outcomes were LCI and capnographic inhomogeneity indices (CII). CII were calculated as the relative end-tidal CO2 concentration differences (%) between the air in the dead space and the total alveolar air (CII1), expired alveolar air (CII2) and alveolar air in the conductive airways (CII3), respectively. Results: CII calculation was feasible in 100% of the trials. LCI and CII1-3 were increased in CF compared to healthy children (LCI 9.2±2.3 vs 7.1±0.6, p Conclusion: CII calculation is feasible in good quality MBW trials. CII correlate with LCI, but show slightly higher variability. VCap is thus a fast and promising VI-test with high potential for clinical use. Further studies on feasibility and methodology to define minimal data quality criteria seem thus justified. |
| Databáze: | OpenAIRE |
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