The Role of β2-Adrenoceptor on the Pathogenesis of Insulin Resistance in Essential Hypertension
| Autor: | Shigeatsu Hashimoto, Shuichi Shigetomi, Soitsu Fukuchi, Zen-o Yamada, Jinchi Kim, Kiyonobu Tanaka |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
business.industry Mabuterol medicine.disease Essential hypertension Norepinephrine (medication) chemistry.chemical_compound Endocrinology Blood pressure Epinephrine Insulin resistance Basal (medicine) chemistry Internal medicine medicine Regular insulin business medicine.drug |
| Zdroj: | Folia Endocrinologica Japonica. 70:521-528 |
| ISSN: | 0029-0661 |
| DOI: | 10.1507/endocrine1927.70.5_521 |
| Popis: | The role of beta 2-adrenoceptor on the pathogenesis of insulin resistance in essential hypertension (EH) was explored. After the measurement of blood pressure in 15 EH patients and 8 control subjects, EH patients were divided into two groups by the elevation of plasma NE (delta NE) 5 min after standing: 7 normoadrenergic EH (delta NE or = 140 pg/ml). On the morning after a 12-h overnight fast, regular insulin (0.1 U/kg) was injected intravenously, and glucose disappearance rate (GDR) was measured and used as an index of insulin sensitivity. On the following day, the test was reinvestigated following the administration of mabuterol, a beta 2 agonist. Plasma growth hormone (GH), cortisol, norepinephrine (NE) and epinephrine (Epi) were measured before and after the mabuterol administration. Although there were no significant differences of basal GDR among these three groups, mabuterol induced a considerable decrease in GDR in EH patients but not in control subjects. There was no significant difference in the decrease of GDR between normo- and hyperadrenergic EH. The decrease in GDR tended to correlate with the mean blood pressure at rest in EH but not in normal subjects. Plasma glucose and serum insulin in EH patients were increased more than in normal subjects. Plasma GH, cortisol and Epi were not elevated by mabuterol, but plasma NE increased in each group, significantly in hyperadrenergic EH. There was no correlationship between the increase in plasma NE and the decrease in GDR after mabuterol.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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