| Popis: |
1-Naphthyl- N -methyl [ 14 C]carbamate (carbaryl), an anticholinesterase, was given orally to pregnant female rats (Day 18). Each rat received 13.5 μCi and was killed 1, 5, 8, 24, 48, 72, and 96 hr later. Whole-body autoradiography was performed. We noted a placental transfer of radioactivity beginning with the first hr. The 14 C concentration in the fetus was relatively constant from 8 to 96 hr. There was localization in the eye, liver, and brain of the fetus. In the mother, 14 C activity was seen in the excretory organs. We noted a localization in bones (medullar), in the digestive tract (wall), and in the brain. Although the major portion of the carbaryl was quickly eliminated, some areas of radioactivity remained in the pregnant rat after oral administration of [ 14 C]carbaryl. This localization occurred particularly in highly active protein building organs (fetus, digestive tract, medullar part of bones). |
