Synthesis of Dihydrochlorides of Azaadamantanes Containing 8-Hydroxyquinoline Fragments and their Antibacterial Activity in Mice with Dysentery and Staphylococcal Infections

Autor:	A. D. Harutyunyan, S. P. Gasparyan, R. V. Paronikyan, G. L. Harutyunyan, G. M. Stepanyan, K. A. Gevorkyan
Rok vydání:	2021
Předmět:	Pharmacology chemistry.chemical_compound Chemistry Drug Discovery Pharmacology toxicology medicine Dysentery 8-Hydroxyquinoline Staphylococcal infections medicine.disease Antibacterial activity In vitro Microbiology
Zdroj:	Pharmaceutical Chemistry Journal. 54:1205-1208
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-021-02344-w
Popis:	New azaadamantane derivatives containing 8-hydroxyquinoline fragments were synthesized. Their antibacterial activity was studied. The synthesized compounds exhibited high antibacterial activity in vitro. The 6-oxo-5,7-diethyl- and 5,7-dimethyl-2-(8'-hydroxyquinolyl-5')-1,3-diazaadamantane dihydrochlorides showed therapeutic effects in mice with dysentery and staphylococcal infections.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e6f8696d60acda325e0ade559eb50b22 https://doi.org/10.1007/s11094-021-02344-w Zobrazit plný text záznamu Plný text ve formátu PDF