The Tumor Necrosis Factor-A -308 G/A Polymorphism and the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Polymorphisms, in Asthmatic Patients and Healthy Subjects
| Autor: | Hilmi Isi, G. Ates, C. Sinir, Mehmet Emin Erdal, Özlem İzci Ay, Gözde Türköz, T. Yildiz, Diclehan Oral |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Biotechnology & Biotechnological Equipment. 24:1638-1643 |
| ISSN: | 1314-3530 1310-2818 |
| DOI: | 10.2478/v10133-010-0018-2 |
| Popis: | Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. Like other atopic diseases, asthma is a complex disorder caused by interactions between multiple genes of small to modest effect and equally important environmental factors. The aim of this study was to determine the TNF-α -308 g/a polymorphism and the TRAIL polymorphisms, and their influence on asthma in asthmatic patients and healthy subjects. The study population consists of 51 asthmatic patients (47 female and 4 male) and 72 healthy subjects (62 female and 10 male). The mean age of the asthmatic patients and healthy controls were 45.33±14.05, and 41.88±17.41 years, respectively. The asthmatic patients and healthy controls were similar with respect to their ages and sex characters. There was statistically a significant difference between the asthmatic patients and control groups in terms of TRAIL Arg141His, G422A (rs6557634) polymorphism (p=0.02). Statistically, there was not any significant difference between the asthmatic patients and control groups for TRAIL Thr209Arg, C626G (rs20575) TRAIL Glu228Ala, A683C (rs20576) and polymorphisms (p=0.57). Also, there was no significant difference between the asthmatic patients and control groups in terms of TNF-α-308 G/A polymorphism (p=0.90). In our study, the TRAIL Arg141His G422A (rs6557634) polymorphism was detected for the first time in asthmatic patients, which may influence the susceptibility to the asthma. |
| Databáze: | OpenAIRE |
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