Melatonin Avoids Anatomofunctional Changes Associated to Aging in a Rat Model
| Autor: | Bertha Prieto Gómez, Cruz Reyes-Vazquez, Mireya Velázquez-Paniagua |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
endocrine system
medicine.medical_specialty Antioxidant medicine.medical_treatment Hippocampus Ocean Engineering Biology Melatonin Pineal gland Endocrinology medicine.anatomical_structure Cell surface receptor Internal medicine medicine Secretion Circadian rhythm hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Zdroj: | Advances in Aging Research. :318-325 |
| ISSN: | 2169-0502 2169-0499 |
| DOI: | 10.4236/aar.2014.34041 |
| Popis: | Melatonin is a hormone synthesized and released primarily by the pineal gland. Its secretion fol-lows a circadian rhythm with a peak overnight. Its secretion is initiated approximately to the three months of age and continues to rise during the childhood. Previous to the puberty there is a de-crease of melatonin secretion that continues until the old age. Melatonin has effects in the body and acts through at least four mechanisms: membrane receptors, orphan nuclear receptors, calmodulin and free radicals. It has been suggested that aging can be a consequence of the oxidation of cells that eventually become vulnerable to injury and die. This work reviews the antioxidant effects of melatonin in a rodent model, on the formation of free radicals, on the MAP2 protein expression and on the electrophysiology of the hippocampus at different ages. The results indicate that melatonin maintains in a “best” state to the experimental animals compared to controls. It suggests the use of melatonin as a therapy to prevent or delay the aging effects on the cells. |
| Databáze: | OpenAIRE |
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