The effect of mesenchymal stem cell donor age on the density of the pia microvascular network in the cerebral cortex of old recipient rats

Autor:	I. V. Sergeev, M. V. Puzanov, Sergey V. Anisimov, D. P. Dvoretsky, I. B. Sokolova
Rok vydání:	2015
Předmět:	Pathology medicine.medical_specialty Pia mater Compartment (ship) Mesenchymal stem cell Anatomy Biology Microcirculation Transplantation Microvascular Network medicine.anatomical_structure Cerebral cortex In vivo medicine Geriatrics and Gerontology Gerontology
Zdroj:	Advances in Gerontology. 5:94-98
ISSN:	2079-0589 2079-0570
DOI:	10.1134/s2079057015020113
Popis:	We transplanted syngenetic bone marrow mesenchymal stem cells (BM MSCs) obtained from 3- to 4-month-old or 20- to 22-month-old donors into the brain of 22- to 24-month-old male Wistar–Kyoto rats. Using a TV device to study microcirculation in vivo, we found that transplantation of BM MSCs from young donors increased the densities of the microvascular network in the pia mater of the sensorimotor cortex and of the arteriolar compartment in old rats approximately by values of 1.9 and 2.1 as compared to agematched controls. Transplantation of BM MSCs from old donors did not significantly influence the density of the microvascular network in the pia mater, while the density of the arteriolar compartment increased by approximately 1.5 times.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e6676e1c2e4cbd1d99d9e10ce4c098f9 https://doi.org/10.1134/s2079057015020113 Zobrazit plný text záznamu Full text from SpringerLink