Vitamin K Antagonist Therapy Is a Risk Factor for Ulcer Development and Death Among Dialyzed Patients
| Autor: | Marco Brambilla, Andreana De Mauri, Massimo Torreggiani, Doriana Chiarinotti |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Heart disease medicine.drug_class business.industry medicine.medical_treatment 030232 urology & nephrology Hematology Disease 030204 cardiovascular system & hematology Vitamin K antagonist medicine.disease Gastroenterology Surgery 03 medical and health sciences 0302 clinical medicine Nephrology Diabetes mellitus Internal medicine Cohort medicine Hemodialysis Risk factor Complication business |
| Zdroj: | Therapeutic Apheresis and Dialysis. 21:150-156 |
| ISSN: | 1744-9979 |
| DOI: | 10.1111/1744-9987.12507 |
| Popis: | Peripheral artery disease is a common complication among dialyzed patients. Since Vitamin K antagonists promote metastatic calcifications and these are the main determinants of vascular damage, we investigated their role in the development of lower limb ulcers in dialyzed patients. We retrospectively enrolled 316 dialyzed patients, aged 68 ± 15 years, 65% male, 32% diabetic, 43% with ischemic heart disease and followed them for 36 ± 25 months. 60 patients assumed Vitamin K antagonists: they were older, with a higher prevalence of heart disease, at greater risk of death and they developed more ulcers and underwent more lower limb amputations compared to the rest of our cohort. Peripheral artery disease, Vitamin K antagonists and diabetes were independent risk factors for foot lesions. In addition, Vitamin K antagonists were also an independent risk factor for death. Vitamin K antagonists are a potent independent risk factor for the development of the uremic foot syndrome and death. |
| Databáze: | OpenAIRE |
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