Formation of Biomolecular Condensates: Regulation of Embryogenesis at the Cellular Level
| Autor: | Eugene V. Sheval, Maria A Tikhomirova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0303 health sciences Mechanism (biology) Chemistry Embryogenesis 01 natural sciences Embryonic stem cell Cell biology 03 medical and health sciences medicine.anatomical_structure Cytoplasm Organelle medicine Nucleus Developmental biology Biogenesis 030304 developmental biology 010606 plant biology & botany Developmental Biology |
| Zdroj: | Russian Journal of Developmental Biology. 52:65-74 |
| ISSN: | 1608-3326 1062-3604 |
| DOI: | 10.1134/s1062360421020077 |
| Popis: | Many morphogenetic processes during ontogenesis are determined by changes in the structure and functions of embryonic cells. The greatest plasticity of the cellular organization is given by membrane-less organelles or biomolecular condensates, which can be formed in the nucleus or cytoplasm by the mechanism of liquid–liquid phase separation. The flexibility of biogenesis of biomolecular condensates and the high dynamics of their components make it possible to change the cellular organization quickly, which leads to changes in the fate of cells, and, as a result, in the course of embryogenesis. In this review, using the example of germ granules, one of the types of membrane-less structures, the relationship between the plasticity of cellular organization and the implementation of early embryogenesis processes is discussed. |
| Databáze: | OpenAIRE |
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