Grade of deceased donor liver macrovesicular steatosis impacts graft and recipient outcomes more than the Donor Risk Index

Autor:	Pamela Dilworth, David Joseph, Henry Pleass, Simone I. Strasser, Esther de Graaf, James G. Kench, Geoff McCaughan, Deborah Verran, Michael Crawford, Nicholas A. Shackel
Rok vydání:	2012
Předmět:	Deceased donor medicine.medical_specialty Hepatology business.industry Gastroenterology Microvesicular Steatosis Macrovesicular steatosis medicine.disease Surgery Transplantation Risk index Relative risk Internal medicine medicine Steatosis business Body mass index
Zdroj:	Journal of Gastroenterology and Hepatology. 27:540-546
ISSN:	0815-9319
DOI:	10.1111/j.1440-1746.2011.06844.x
Popis:	Background and Aim: Donor liver steatosis can impact on liver allograft outcomes. The aim of the present study was to comprehensively report on the impact of type and grade of donor steatosis, as well as donor and recipient factors, including the reported Donor Risk Index (DRI), on liver allograft outcomes. Methods: Areview of unit data for all adult liver transplant procedures from 2001 to 2007, as well as donor offers. Donor liver biopsies were regraded for steatosis by an experienced histopathologist. Results: Steatosis was detected in 184/255 (72%) of biopsies, of which 114 (62%) had microvesicular steatosis (MiS; 68 mild, 22 moderate, 24 severe) and 70 (38%) macrovesicular steatosis (MaS; 59 mild, 7 moderate, 4 severe). The majority (66/70, 94%) of biopsies with MaS also contained MiS. Allograft steatosis was associated with increasing donor body mass index (P = 0.000), plus donor male sex (P
Databáze:	OpenAIRE
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