The immune system's first steps

Autor: Seth Thomas Scanlon
Rok vydání: 2020
Předmět:
Zdroj: Science. 368:598-599
ISSN: 1095-9203
0036-8075
DOI: 10.1126/science.abc3140
Popis: In the early 1950s, Peter Medawar and colleagues showed that transplant tolerance could be induced in adult mice by inoculating them in utero with cells from a donor strain. This elegant experiment revealed that the immune system in early life is functionally distinct and responsive to programming that persists into adulthood. Nearly 70 years later, the complexity and developmental trajectory of the fetal–neonatal immune system are much better understood. We have also begun to appreciate that the immune system in early life does not develop in isolation but is instead strongly infl uenced by maternal cells, commensal microbes, and pathogens. This special issue surveys recent advances in the fi eld of early life immunology. Review articles highlight distinctive features of human fetal immune system development elucidated by unbiased multi-omics analysis, the impact of commensal metabolites and xenobiotics on immunity before and after birth, how maternal and fetal immune components work together to combat viral infections during pregnancy (and what happens when these mechanisms fail), and the potential of vaccination approaches to boost fetal–maternal immunity and protect neonates against the pathogens that most frequently cause them harm. These discoveries should inform future public health initiatives and draw renewed attention to the vulnerability of children in early life, laying the groundwork for vaccination strategies to target pathogens that cause congenital and neonatal infections as well as therapies to treat disorders such as stillbirth and prematurity. Evidence is also mounting that immune system programming that starts in early life may influence the risk of developing conditions such as allergic, autoimmune, reproductive, and neuropsychiatric disorders in later life, further underscoring the translational implications of this kind of research.
Databáze: OpenAIRE
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