Haematological recovery in poor and good haematopoietic stem cell mobilisers
| Autor: | Luciana Camargo de Oliveira, Belinda Pinto Simões, Maristela Delgado Orellana, G C De Santis, Benedito de Pina Almeida Prado, A. C. Garcia-Silva, N. C. G. Chiaramonte, Dimas Tadeu Covas |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Cell CD34 Hematology 030204 cardiovascular system & hematology Biology Gastroenterology Transplantation 03 medical and health sciences Haematopoiesis 0302 clinical medicine medicine.anatomical_structure Internal medicine Immunology medicine Platelet Bone marrow Stem cell Progenitor cell 030215 immunology |
| Zdroj: | Transfusion Medicine. 26:297-300 |
| ISSN: | 0958-7578 |
| Popis: | SUMMARY Objectives Evaluate whether poor mobilisers had delayed haematopoietic (neutrophil and platelet) recovery despite receiving similar cell dose as good mobilisers. Background Autologous haematopoietic progenitor cell (HPC) transplantation is indicated to treat some haematological malignancies. This procedure requires HPC mobilisation from bone marrow to peripheral blood. Cell dose is important for a fast haematological recovery. Despite being poor mobilisers, some patients can collect enough cell numbers for transplantation. Results Fifteen poor mobiliser patients (peak of CD34+ cells ≤10 µL−1 in peripheral blood) were transplanted at our institution. Haematological recovery (neutrophil ≥ 500 µL−1) in this group was compared to that observed in the group of 16 patients of good mobilisers (peak of CD34+ cells ≥20 µL−1 in peripheral blood) who received similar cell dose (2·637 ± 0·1744 × 106 kg−1 vs 2·727 ± 0·1746 × 106 kg−1; P = 0·7177). The poor mobiliser group had neutrophil and platelet recovery later than the good mobiliser group (on day 12, range 9–14 vs day 10, range 9–22, P = 0·0381 for neutrophil, and on day 22·89 ± 11·16 and 14·08 ± 4·821, P = 0·0193 for platelet). Mortality rates and transfusion requirements were not different between the groups. Conclusion Poor mobilisers have delayed neutrophil and platelet recovery after autologous HPC transplantation despite having received the same cell dose as good mobilisers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|