| Autor: |
Zhi-Wei Ma, Zhi-Jing Liu, Xiao-Pei Chen, Chuan-Chuan Wang, Jun-Tao Liu, Jing-Chao Tao |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Letters in Organic Chemistry. 19:1042-1046 |
| ISSN: |
1570-1786 |
| DOI: |
10.2174/1570178619666220314152530 |
| Popis: |
Abstract: A novel tertiary amine squaramide has been successfully developed and applied to catalyze the asymmetric Michael addition between cyclic diketones and β,γ-unsaturated α-ketoesters. The catalyst system performed well with a low catalyst loading of 1 mol% under mild reaction conditions. A series of synthetically and pharmaceutically useful chiral bicyclic compounds were obtained with both high yields (up to 97%) and excellent enantioselectivities (up to 97% ee). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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