| Autor: |
Safia Noreen, Samia Hassan, Mahwish Iqbal, Tayyba Rehman, Zohaib Zafar, Iqra Khawaish, Arifa Murtaza, Muhammad Haseeb Anwar Tarar |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of Pharmaceutical Research International. :202-215 |
| ISSN: |
2456-9119 |
| Popis: |
Poor aqueous solubility is the principle obstacle in accomplishing suitable oral bioavailability for huge proportion of drug composites in drug development todays. Nano-suspension is an emerging field of research in the scientific community to provide a new solution for poorly water-soluble active constituents. The objective of the nano-suspension is to reduce the drug particle size (100-200 nm) range, which enhance solubility and bioavailability of biopharmaceutical active compounds. Crude extract of Piper nigrum shows various biological activities but poor aqueous solubility so, there is a need to isolate the piperine from Piper nigrum and prepare its nano-suspension to reduce particle size and enhance its bioavailability. This review defines the principles behind nanosizing, the synthesis and characterization of piperine nano-suspension as well as the recent practice withapplication of such formulations in-vivo can be used as a better alternative to treat cardiovascular diseases with improved therapeutic efficacy compared to extract. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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