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Introduction: Patients with sarcoidosis (SC) and tuberculosis (TB) can develop a small fiber neuropathy (SFN), that is worsening the prognosis. Aim: To investigate the clinical manifestation of SFN in patients with SC and TB. Materials and Methods: In 2018-19, patients with histologically verified pulmonary SC (17 men, 5 women, aged 33.4±8.5 years), 16 patients with pulmonary TB in the pre-treatment period (9 men, 10 women, aged 36.6±9.3 years) and 73 healthy subjects (HS, 43 men, 30 women, aged 53,5±13,92 years) were included. A complete neurological investigation was performed. The questionnaire “Small fiber neuropathy screening list in sarcoidosis” (SFN-SL) was used as a validated test for the SFN evaluation. Statistical analysis was performed with Statistica 8.0 (StatSoft, Inc., USA). Differences were significant at p Results and Discussion: The average score for SFN-SL scale in patients with SC was 2.0 (0;7.3) points, 15/67.9% of them described symptoms of SFN. The majority of patients with TB had no SFN complains (average score 0.2 (0;0.4) points), only 4/21% had typical neurologic symptoms. HS had 0 (0;0) points, 1/1.4% had SFN complaints. Patients with SC had higher SFN scores in comparison with TB (p=0.001) and HS (p Conclusion: In patients with SC the manifestation of neuropathy of small fibers was described more frequent, that requires verification and prescription of therapy. TB patients had more frequent SFN symptoms than HS, that may require immunological studies. |
