Levamisole derivatives as immune modulators for the treatment of amyotrophic lateral sclerosis (ALS)

Autor:	Simon DP Baugh, Jessica R Morrice, Allen B Reitz, Christopher A Shaw, Cheryl Y Gregory-Evans
Rok vydání:	2023
Předmět:	Pharmacology Drug Discovery Molecular Medicine
Zdroj:	Future Medicinal Chemistry. 15:651-659
ISSN:	1756-8927 1756-8919
Popis:	Aim: To discover derivatives of the anthelmintic drug levamisole, which has been reported to possess immune-modulatory properties, as treatments for amyotrophic lateral sclerosis (ALS), which has been suggested to be in part an autoimmune disease. Results: We have synthesized ten analogs of the racemic version of levamisole, tetramisole, as well as eleven analogs on a related system. All of the analogs have been tested for their ability to affect the response of five ALS-relevant cytokines. Conclusion: We have discovered a number of interesting derivatives that have encouraging cytokine response data and good metabolic stability, with the potential to have a positive impact on ALS either as single agents, or in combination.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e4bf7b5da12772a87cb968b76da74d86 https://doi.org/10.4155/fmc-2023-0028 Zobrazit plný text záznamu