| Popis: |
In order to test certain hypotheses regarding the cause of arterial hypoxia during haemodialysis(HD),we investigated the effect of:- 1 Heparin bolus-infusion; or heparin plus:- 2.Prostacyclin ( PGI2 ) infusion ( 5ng/Kg/mi n );3. Methyl Prednisolone bolus(30mg/Kg) 30 minutes prior to dialysis; 4. Ultrafiltration for one hour followed by dialysis(UF/HD); 5.40mmo1/l Bicarbonate dialysate instead of standard acetate dialysate . Seven patients on long term HD were examined by all methods. Arterial blood samples were taken before,and at intervals during ,dialysis for blood gases, platelet count,and neutrophil count. All results are expressed as percentage of pre-dialys is value (means).Results fo r each group were tested fo r significance against the Heparin group(l.)using a paired t tes t . The only significant sparing of hypoxia occurred at 60 minutes during UF/HD.PGI2 spared platelets , as we have previously shown. Methyl Prednisolone failed to prevent dialysis induced neutropenia. The mechanism of haemodialysis induced hypoxia remains obscure |
