Preparation and antimicrobial activity of a new palladium(II) complexes with a coumarin-derived ligands. Crystal structures of the 3-(1-(o-toluidino)ethylidene)-chroman-2,4-dione and 3-(1-(m-toluidino) ethylidene)-chroman-2,4-dione
| Autor: | Ivan Potočňák, Srećko R. Trifunović, Ljiljana R. Čomić, Edina H. Avdović, Dejan Milenković, Nenad Vuković, Verica V. Jevtić, Danijela Lj. Stojković, Ivana D. Radojević, Zoran Marković |
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| Rok vydání: | 2019 |
| Předmět: |
010405 organic chemistry
chemistry.chemical_element Crystal structure 010402 general chemistry Antimicrobial Coumarin 01 natural sciences Medicinal chemistry Microanalysis 0104 chemical sciences Inorganic Chemistry Minimum inhibitory concentration chemistry.chemical_compound 13c nmr spectroscopy chemistry Materials Chemistry Physical and Theoretical Chemistry Palladium |
| Zdroj: | Inorganica Chimica Acta. 484:52-59 |
| ISSN: | 0020-1693 |
| Popis: | The five coumarin derivatives 3-(1-(2-hydroxypropylamino)ethylidene)-chroman-2,4-dione (L1), 3-(1-(phenylamino)ethylidene)-chroman-2,4-dione (L2), 3-(1-(o-toluidino)ethylidene)-chroman-2,4-dione (L3), 3-(1-(m-toluidino)ethylidene)-chroman-2,4-dione (L4), 3-(1-(2-mercaptoethylamino)ethylidene)-chroman-2,4-dione (L5) and its corresponding complexes 3-(1-(2-hydroxypropylamino)-ethylidene)-chroman-2,4-dione-palladium(II) (C1), 3-(1-(phenylamino)-ethylidene)-chroman-2,4-dione-palladium(II) (C2), 3-(1-(o-toluidino)-ethylidene)-chroman-2,4-dione-palladium(II) (C3), 3-(1-(m-toluidino)ethylidene)-chroman-2,4-dione-palladium(II) (C4), 3-(1-(2-mercaptoethylamino)ethylidene)-chroman-2,4-dione-palladium(II) (C5), were synthesized and characterized with microanalysis, infrared, 1H and 13C NMR spectroscopy. The proposed structures of ligands L3 and L4 were confirmed on the basis of the X-ray structural study. The ligands and their complexes were tested for their in vitro antimicrobial activity against 17 species of bacteria and fungi. Testing is performed by the microdilution method, with the minimum inhibitory concentration (MIC) and the minimum microbicidal concentration (MMC) being determined. |
| Databáze: | OpenAIRE |
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