FAMILY STUDY SHOWING A CLOSE ASSOCIATION OF HLA DPB1*0202/0901 WITH ULCERATIVE COLITIS

Autor:	Tomomi Nishimura, Tatsuyoshi Saiga, Hiroo Furukawa, Takuya Hiratsuka, Hisako Morichi, Takayuki Moriyasu, Yasushi Ohmori
Rok vydání:	2006
Předmět:	Genetics MHC class II biology HLA-DPB1 business.industry Haplotype Gastroenterology Human leukocyte antigen Major histocompatibility complex medicine.disease Ulcerative colitis Immunology biology.protein Genetic predisposition Medicine Radiology Nuclear Medicine and imaging Typing business
Zdroj:	Digestive Endoscopy. 18:225-228
ISSN:	1443-1661 0915-5635
DOI:	10.1111/j.1443-1661.2006.00630.x
Popis:	Genetic disposition and environmental factors are closely related to the occurrence of ulcerative colitis (UC). The HLA haplotypes of major histocompatibility complex (MHC) Class II are considered to be the most important genetic factors in UC. The current report focuses on the genetic human leukocyte antigen (HLA) of a family in which UC crises have occurred in five of six members with identical MHC Class II haplotypes. Haplotypes A24/26 (A24/-), BW4/6 (BW4/-) and DQ1/3 (DQ1/-) were found in all six members of the family. In DNA typing, characteristic loci common to this family were seen in DRB11502 and DQB10601. From the genetic investigation of this family, we concluded that HLA haplotypes are the most important genetic factors in the occurrence of UC.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e332d12b4bca3cb9ae0f71e5091b7444 https://doi.org/10.1111/j.1443-1661.2006.00630.x Zobrazit plný text záznamu Plný text ve formátu PDF