The effect of electrospinning parameters on the compliance behavior of electrospun polyurethane tube for artificial common bile duct
| Autor: | Dariush Semnani, Hossein Hasani, Mehdi Sadrjahani, Mohammad Rafeinia, Najmeh Moazeni, Mitra Naeimi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Polymers and Plastics Common bile duct medicine.medical_treatment 0206 medical engineering Rotational speed 02 engineering and technology 021001 nanoscience & nanotechnology 020601 biomedical engineering Prosthesis Electrospinning Volumetric flow rate Taguchi methods Mandrel medicine.anatomical_structure Materials Chemistry medicine Tube (fluid conveyance) Composite material 0210 nano-technology |
| Zdroj: | Polymer Science, Series A. 59:67-75 |
| ISSN: | 1555-6107 0965-545X |
| Popis: | The present research introduced a method to produce an artificial common bile duct using electrospinning technique. Also, the effect of electrospinning variables on the mechanical properties of produced prostheses is investigated. Using electrospinning of polyurethane nanofibres, cylindrical prostheses were produced on a rotating mandrel considering the different controllable factors such as the mandrel rotational speed, the applied voltage, and the flow rate of polymer solution. Taguchi method was used to investigate the effect of mentioned factors on the compliance of circular prostheses. MTT assay was performed to study the cytotoxicity of prostheses. The results of the signal-to-noise analysis showed that the mandrel rotational speed factor has the strongest effect on the compliance values. The flow rate was the second factor and it was followed by electrospinning voltage. In addition, the optimum conditions to reach the highest compliance value were determined. The results of MTT assay indicated no cytotoxic effects of prostheses on the cells. The compliance of optimum prosthesis was found close to the compliance value of a native common bile duct. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink