Xanthan Matrix as Drug ZDelivery System
| Autor: | Florica Doroftei, Narcis Anghel, Maria Valentina Dinu, Iuliana Spiridon |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Matrix (mathematics)
Materials science Chemical engineering Process equipment Petrochemistry Materials Science (miscellaneous) Process Chemistry and Technology Materials Chemistry General Engineering General Chemistry General Medicine General Pharmacology Toxicology and Pharmaceutics General Biochemistry Genetics and Molecular Biology |
| Zdroj: | Revista de Chimie. 72:90-99 |
| ISSN: | 2668-8212 0034-7752 |
| DOI: | 10.37358/rc.21.1.8406 |
| Popis: | Here we present a new drug delivery system based on xanthan esterified with acrylic acid. This material served as a matrix for the incorporation of bioactive substances with antimicrobial and anti-inflammatory properties. The materials were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR) and Scanning Electron Micrography (SEM). Mechanical strength tests showed a substantial improvement in the resilience and flexibility of the polymer matrix modified by esterification under conditions of mechanical stress. The release of bioactive substances from the basic matrix follows a Korsmeyer-Peppas type kinetics. The modified xanthan-based transport system was shown to be antimicrobially active with an inhibition rate of almost 100% on gram-positive and gram-negative bacteria. The obtained results recommend this biomaterial for the manufacture of transdermal drug delivery devices. |
| Databáze: | OpenAIRE |
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